As genomic testing becomes more mainstream, sequencing our 3.2 billion DNA base pairs is critical to identifying mutations that can cause disease. Advancements in high-throughput instruments have decreased the cost of sequencing, which only increases the amount of data that requires analysis. Parallelized workflows on GPUs and AI improve instrument throughput and accuracy, while accelerating analysis.
NVIDIA® Parabricks® is the only GPU-accelerated bioinformatics solution that delivers fast and accurate analysis for sequencing centers, clinical teams, genomics researchers, and next-generation sequencing instrument developers.
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In January 2022, the New England Journal of Medicine published a record-breaking technique where a whole genome was sequenced in 7 hours and 18 minutes. This ultrarapid workflow offers hope for patients with undiagnosed or rare genetic diseases. The team, which included Stanford, Oxford Nanopore, NVIDIA, the University of California, Santa Cruz (UCSC), and Google, accelerated every step, from sample processing to variant curation. AI was instrumental in basecalling, alignment, and variant calling. NVIDIA and Oxford Nanopore have further optimized the analysis pipeline on a single NVIDIA DGX™ A100, achieving state-of-the-art performance and reducing compute costs by over 50 percent.
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