For precision medicine to become routine, more must be done to understand human genetic variations and how they contribute to diseases and disorders. This requires high-confidence variant catalogues, comprehensive annotations, and approaches to genome-wide analytics that drive new understandings in human biology and medicine. GPU-based parallel processing of sequencing data is now addressing the myriad bottlenecks that occur across the computational workflow. With performance of up to 60x acceleration for state-of-the-art bioinformatics tools and complete end-to-end workflows in under 25 minutes, larger sequencing projects are becoming less expensive, easier to manage, and generating more useful insights than ever before. NVIDIA is delivering this accelerated compute framework to detect and annotate genetic variants. This session will provide an overview of Clara Parabricks Pipelines, including several use cases from population studies to single-cell applications.