Quantum circuit simulation is a vital tool for answering some of the most important and pressing questions in quantum computing, for both fundamental research and application to industry use cases. The DGX cuQuantum Appliance from NVIDIA is a software container that represents a full quantum circuit simulation solution, optimized for the DGX A100 and with best-in-class performance on key quantum algorithms. We'll introduce the DGX cuQuantum Appliance and benchmark against other options on the market today. We'll also cover several examples of how cuQuantum on DGX can enable novel research in quantum computing in key application areas, at a scale and performance not possible on quantum processors today.